If you're searching for a filling, flavorful, and easy-to-make dish, look no further than the John Wayne Casserole. This Tex-Mex-inspired comfort food is packed with layers of ground beef, vegetables, cheese, and a biscuit-like crust that’s perfect for any meal. Whether you’re making dinner for the family or need something to impress at a potluck, the John Wayne Casserole is a must-try recipe. Keep reading to learn how to make this tasty dish from start to finish!

What is John Wayne Casserole?
John Wayne Casserole is named after the famous actor John Wayne, who reportedly contributed a recipe similar to this to a cookbook back in the 1970s. This dish typically consists of layers of seasoned ground beef, chopped vegetables, cheese, and a biscuit base or cornbread crust. The flavors blend together to create a rich, comforting meal that’s both filling and packed with Tex-Mex flavors.
Ingredients List for John Wayne Casserole
To create a delicious John Wayne Casserole, you’ll need the following ingredients:
- 1 pound ground beef – The base of this dish is seasoned beef, adding a savory depth of flavor.
- 1 packet taco seasoning – Adds a zesty kick to the beef, giving it a Tex-Mex flare.
- ½ cup water – Helps mix the seasoning into the beef.
- 1 can (10 oz) diced tomatoes with green chilies (Rotel) – This adds both moisture and flavor with a little extra spice.
- 1 medium onion, diced – For added crunch and sweetness.
- 1 medium green bell pepper, diced – Provides a mild peppery flavor and a bit of color.
- 1 medium red bell pepper, diced – Adds sweetness and a bright red hue to the casserole.
- 2 cups shredded cheddar cheese – Cheesy goodness binds the layers together and melts on top.
- 1 cup sour cream – Adds creaminess and balances the spiciness.
- 1 cup mayonnaise – A key ingredient for richness in the casserole.
- 2 cups Bisquick mix – Used for making the base of the casserole, this forms a biscuit-like crust.
- ½ cup water or milk – Needed to combine with the Bisquick for the crust.
- 1 tablespoon butter – For greasing the baking dish.
Substitutions and Variations
If you're short on certain ingredients or prefer a slightly different flavor profile, there are a few simple substitutions and variations you can try:
- Ground Turkey or Chicken: Swap out ground beef for ground turkey or chicken if you’re looking for a leaner option.
- Vegetarian Version: Skip the meat and use black beans or a meat substitute like soy crumbles instead. Add extra veggies like zucchini or mushrooms to bulk it up.
- Spice Level: If you prefer less heat, use mild diced tomatoes without green chilies, or choose a milder taco seasoning. If you love spice, add jalapeños or use spicy Rotel.
- Dairy-Free Version: Replace the cheese and sour cream with dairy-free alternatives, and use a dairy-free mayo.
- Cornbread Crust: Instead of the Bisquick mix, you can use a boxed cornbread mix for a sweet and savory twist on the crust.
Step-by-Step Cooking Instructions

Now that you have your ingredients ready, it’s time to prepare this tasty casserole. The process is simple and straightforward, perfect for both novice and experienced cooks alike.
- Preheat the oven to 350°F (175°C). Grease a 9x13-inch baking dish with butter or nonstick spray.
- Cook the ground beef: In a large skillet over medium heat, cook the ground beef until browned and fully cooked. Drain off any excess grease.
- Add seasoning: Stir in the taco seasoning and ½ cup water, cooking for another 2-3 minutes until the beef is well coated and the liquid has reduced.
- Prepare the vegetables: While the beef is cooking, dice the onions, green bell pepper, and red bell pepper. Add them to the skillet with the beef and sauté for about 5 minutes, until they start to soften.
- Mix in the tomatoes: Stir in the can of diced tomatoes with green chilies. Let everything simmer together for an additional 3-5 minutes to meld the flavors.
- Make the Bisquick crust: In a medium bowl, mix together the Bisquick and ½ cup of water or milk to form a dough. It should be slightly sticky but workable.
- Layer the casserole: Press the Bisquick dough into the bottom of the greased baking dish, spreading it evenly to create the base. Pour the beef and veggie mixture over the dough.
- Add the creamy topping: In a separate bowl, combine the sour cream and mayonnaise. Spread this mixture evenly over the beef and veggie layer.
- Top with cheese: Sprinkle the shredded cheddar cheese on top of the sour cream mixture, covering the entire casserole.
- Bake: Place the casserole in the preheated oven and bake for 30-35 minutes, or until the top is golden and bubbly.
- Let it cool: Remove from the oven and allow the casserole to cool for 10 minutes before serving.
How to Cook John Wayne Casserole: A Step-by-Step Guide
Cooking the John Wayne Casserole is easier than you might think! Here's a breakdown of the steps to make sure you get perfect results every time:
- Cook the Ground Beef: Browning the beef is essential for getting the right texture. Make sure you drain the excess grease to avoid making the casserole too oily.
- Sauté the Vegetables: Cooking the onions and bell peppers before baking softens them and allows their flavors to integrate seamlessly into the casserole.
- Assemble the Layers Carefully: Start with the Bisquick crust on the bottom, followed by the beef mixture, sour cream topping, and finally the cheese. This layering is crucial for getting the right bite with every forkful.
- Bake Until Bubbly: Bake the casserole until the cheese is melted and golden, and the edges of the biscuit crust are crisp.
Common Mistakes to Avoid
- Overloading the Crust: Too much filling can make the crust soggy. Stick to the recommended ingredient quantities for best results.
- Skipping the Drain: Always drain excess fat from the cooked beef, or your casserole may turn out greasy.
- Undercooking the Vegetables: While the casserole will cook in the oven, you want your vegetables to be slightly softened before they go into the dish.
- Overbaking: Keep an eye on the casserole after 30 minutes. You want the top golden but not burned.
Serving and Presentation Tips
Once your John Wayne Casserole has cooled slightly, it’s ready to be served. But don’t just scoop it onto plates—presentation matters!
How to Serve John Wayne Casserole
Serve John Wayne Casserole with a side of Mexican rice, refried beans, or a fresh green salad to balance out the rich flavors. For a Tex-Mex theme, garnish with chopped cilantro, jalapeños, and a dollop of guacamole or extra sour cream.
Presentation Ideas for John Wayne Casserole
Consider serving the casserole in individual portions on colorful plates to highlight the layers of beef, veggies, and cheese. A sprinkle of fresh cilantro or chopped green onions on top adds a pop of color. You can also place the casserole on a rustic wooden board for a hearty, Western-inspired table setting.
John Wayne Casserole Recipe Tips
- Make Ahead: This casserole can be prepared up to a day in advance. Simply assemble it, cover, and refrigerate until you’re ready to bake.
- Freeze for Later: You can also freeze the uncooked casserole for up to 3 months. Thaw overnight in the refrigerator before baking.
- Customize Your Layers: Feel free to experiment with different vegetables or cheese types to suit your family’s taste.
Frequently Asked Questions (FAQs)
Can I make John Wayne Casserole gluten-free?
Yes! You can use a gluten-free baking mix instead of Bisquick to make the crust, and check that your taco seasoning and other ingredients are certified gluten-free.
Can I prepare this casserole in advance?
Absolutely! You can assemble the casserole and store it in the fridge overnight. Bake it the next day when you're ready to serve.
How can I store leftovers?
Leftovers can be stored in an airtight container in the fridge for up to 4 days. Reheat in the oven at 350°F until warmed through, or microwave individual portions.
What are good side dishes for John Wayne Casserole?
Mexican rice, refried beans, or a fresh garden salad make excellent side dishes for this casserole.
Conclusion
The John Wayne Casserole is a perfect recipe for family dinners or potlucks, combining hearty ingredients with bold Tex-Mex flavors. It's easy to customize, quick to assemble, and incredibly satisfying. Whether you stick to the classic recipe or put your own spin on it, this casserole is sure to become a favorite in your household. Give it a try tonight, and watch it disappear from the table!
PrintJohn Wayne Casserole Recipe
John Wayne Casserole is a delicious, hearty dish featuring layers of ground beef, vegetables, cheese, and a biscuit crust. It's a satisfying comfort food meal that your family will love. This casserole is baked to perfection and combines savory flavors with a slight Tex-Mex twist.
- Prep Time: 15 minutes
- Cook Time: 30 minutes
- Total Time: 45 minutes
- Yield: 6-8 servings 1x
- Category: Main Course , casserole
- Method: Baking
- Cuisine: American, Tex-Mex
- Diet: Low Calorie
Ingredients
- 2 lbs ground beef
- 1 package taco seasoning
- 1 can (10 oz) diced tomatoes with green chilies, drained
- 1 small onion, chopped
- 1 bell pepper, chopped
- 2 cups cheddar cheese, shredded
- 1 can (8 oz) refrigerated biscuits
- 1 cup sour cream
- 1 cup mayonnaise
- 1 package (1 oz) ranch dressing mix
- 1 can (4 oz) diced green chilies
Instructions
- Preheat oven to 350°F (175°C).
- Cook ground beef in a large skillet over medium heat until browned; drain excess fat.
- Add taco seasoning, diced tomatoes with green chilies, onion, and bell pepper to the beef mixture. Cook for 5-7 minutes until vegetables soften.
- In a separate bowl, combine sour cream, mayonnaise, and ranch dressing mix.
- Place refrigerated biscuits in the bottom of a greased 9x13-inch baking dish, pressing them flat.
- Layer the beef mixture on top of the biscuits, then spread the sour cream mixture over it.
- Top with shredded cheddar cheese and diced green chilies.
- Bake in the preheated oven for 25-30 minutes until biscuits are cooked through and cheese is melted and bubbly.
- Let it cool for a few minutes before serving.
Notes
- You can substitute ground turkey for beef for a lighter version.
- Add jalapeños for extra spice.
- Best served with a side salad or Mexican rice.
Nutrition
- Serving Size: 1 serving
- Calories: 480
- Sugar: 4g
- Sodium: 1150mg
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