If you're looking for a delicious, easy-to-make casserole that packs a punch of bold flavors, the John Wayne Casserole is the perfect recipe to try. Loaded with layers of ground beef, peppers, onions, and a cheesy biscuit crust, this dish is a crowd-pleaser for family dinners, potlucks, or casual gatherings. Follow along for all the details on how to prepare this flavorful Tex-Mex-inspired casserole. Be sure to read to the end for all the cooking tips, serving suggestions, and answers to common questions!

What is a "John Wayne Casserole"?
The John Wayne Casserole is a layered dish that typically consists of a seasoned ground beef mixture, bell peppers, onions, tomatoes, jalapeños, and a thick, cheesy biscuit crust. This casserole was named after the legendary actor John Wayne, who reportedly contributed a version of this recipe to a cookbook benefiting the American Cancer Society in the 1970s. The flavors are rich and satisfying, with just the right amount of spice and cheesiness, making it a hit for anyone who enjoys hearty comfort food.
Ingredients List for John Wayne Casserole
Before we dive into the cooking process, it's essential to gather all the ingredients needed for this recipe. Here’s a complete list of what you'll need:
- 1 pound of ground beef (preferably lean)
- 1 large onion, diced
- 1 bell pepper, diced (green or red, depending on your preference)
- 1 cup of diced tomatoes (canned or fresh)
- 1 can of diced green chilies (or 2 fresh jalapeños, diced)
- 1 packet of taco seasoning (or 2 tablespoons of homemade taco seasoning)
- 2 cups of shredded cheddar cheese (divided)
- ½ cup of sour cream
- ½ cup of mayonnaise
- 1 cup of biscuit baking mix (such as Bisquick)
- ½ cup of milk
- Salt and pepper to taste
Substitutions and Variations
Like many casseroles, the John Wayne Casserole is versatile and can be customized to fit your preferences or dietary restrictions. Here are some possible substitutions and variations:
- Ground Turkey or Chicken: Instead of ground beef, you can use ground turkey or chicken for a leaner option. The texture and flavor will still be rich and satisfying.
- Vegetarian Option: For a meatless version, replace the ground beef with black beans, pinto beans, or a combination of the two. You can also add more vegetables, such as zucchini or corn, for extra heartiness.
- Cheese Varieties: While cheddar is traditional, you can mix in Monterey Jack, Colby, or pepper jack for added flavor and spice.
- Low-Carb Option: Skip the biscuit mix and replace it with a layer of cauliflower rice or a low-carb tortilla to reduce the carbohydrate content.
- Spice Level: Adjust the heat to your preference by using mild green chilies or adding extra jalapeños or even chipotle peppers for a smoky flavor.
Step-by-Step Cooking Instructions

Now that you have your ingredients, let’s get started with the step-by-step process of preparing your John Wayne Casserole.
Step 1: Preheat the Oven
Preheat your oven to 350°F (175°C). Grease a 9x13-inch baking dish lightly with cooking spray or butter to prevent sticking.
Step 2: Cook the Ground Beef and Vegetables
In a large skillet, cook the ground beef over medium heat until browned and fully cooked. This should take about 7-10 minutes. Drain any excess fat, then add the diced onion, bell pepper, and taco seasoning. Sauté for another 5-7 minutes, or until the vegetables are softened.
Step 3: Add Tomatoes and Chilies
Once the beef and vegetables are well combined, stir in the diced tomatoes and green chilies. Allow the mixture to simmer for an additional 3-5 minutes. Season with salt and pepper to taste. Once done, remove the skillet from the heat and set aside.
Step 4: Prepare the Biscuit Crust
In a medium-sized bowl, combine the biscuit baking mix with the milk, stirring until a soft dough forms. Press the dough evenly into the bottom of your greased baking dish to create the casserole’s crust.
Step 5: Create the Creamy Cheese Layer
In a separate bowl, mix together the sour cream, mayonnaise, and half of the shredded cheddar cheese. Spread this mixture over the biscuit dough layer evenly.
Step 6: Assemble the Casserole
Pour the beef, vegetable, and tomato mixture on top of the creamy cheese layer. Spread it out so that it’s even and covers the entire surface of the baking dish.
Step 7: Top with Cheese
Sprinkle the remaining shredded cheddar cheese over the beef mixture. The cheese will create a gooey, golden top once baked.
Step 8: Bake
Place the assembled casserole in the preheated oven and bake for 30-35 minutes, or until the cheese is melted, bubbly, and slightly golden around the edges.
Step 9: Cool and Serve
Once baked, remove the casserole from the oven and let it cool for about 5 minutes before serving. This allows the flavors to settle and makes it easier to slice and serve.
How to Cook John Wayne Casserole: A Step-by-Step Guide
Cooking the John Wayne Casserole is a simple process, but getting each layer just right ensures the dish turns out perfect. Let’s break it down again:
- Cook the Beef and Veggies: Sautéing the beef with onions, peppers, and taco seasoning creates the flavorful base of the casserole.
- Prepare the Crust: A soft biscuit dough is spread at the bottom, providing a sturdy and delicious foundation.
- Creamy Layer: A combination of sour cream, mayo, and cheese adds richness and tang to the casserole.
- Top It Off: The remaining cheese brings it all together with a golden, melty topping after baking.
Common Mistakes to Avoid
- Overcooking the Beef: Avoid overcooking the ground beef, which can lead to dryness. Cook it just until browned.
- Underseasoning: Be sure to season each layer, especially the ground beef, to ensure the flavors pop.
- Biscuit Crust Mistakes: Ensure the biscuit dough is evenly spread at the bottom of the dish. If it’s too thick in some areas, it won’t cook evenly.
- Cheese Layer Issues: Don’t skimp on the cheese. The creamy and cheesy top is what makes this casserole extra special!
Serving and Presentation Tips
Presentation matters, even for casseroles! Here are a few tips to make your John Wayne Casserole look as good as it tastes.
How to Serve John Wayne Casserole
- Slicing and Plating: After allowing the casserole to cool slightly, use a sharp knife to cut it into square portions. Use a spatula to transfer the slices onto plates.
- Garnishing: Sprinkle some fresh cilantro or green onions on top for a burst of color and added flavor.
- Add Sides: Serve with tortilla chips, salsa, or a fresh salad for a well-rounded meal.
Presentation Ideas for John Wayne Casserole
- Layer Visibility: When slicing, aim to showcase the distinct layers of biscuit, creamy filling, beef, and cheese.
- Serving in Style: For a rustic, homey presentation, serve the casserole directly from the baking dish, allowing guests to help themselves.
John Wayne Casserole Recipe Tips
- Make-Ahead Option: You can prepare the casserole a day ahead and refrigerate it before baking. Just allow a few extra minutes in the oven if baking straight from the fridge.
- Freezing: John Wayne Casserole freezes well. After baking, allow it to cool, then freeze individual portions in airtight containers for up to 3 months.
- Reheating: Reheat leftovers in the oven at 350°F for about 15 minutes, or microwave individual servings for 2-3 minutes.
Frequently Asked Questions (FAQs)
1. Can I make John Wayne Casserole ahead of time?
Yes, this casserole can be assembled ahead of time and stored in the refrigerator for up to 24 hours before baking. Alternatively, you can bake it, freeze portions, and reheat when ready.
2. Can I make this recipe spicier?
Absolutely! To add more heat, include extra jalapeños, chipotle peppers, or a spicy taco seasoning mix.
3. Can I use a different type of cheese?
Yes, feel free to experiment with different cheeses like Monterey Jack, pepper jack, or Colby. They’ll all melt nicely and complement the flavors.
4. What sides go well with John Wayne Casserole?
This dish pairs well with Mexican rice, a simple green salad, or refried beans.
Conclusion
The John Wayne Casserole is a comforting, hearty dish that's perfect for family dinners or gatherings. With its layers of seasoned beef, creamy cheese, and a flaky biscuit crust, it’s sure to become a favorite in your meal rotation. Try out different variations, serve it with your favorite sides, and enjoy this Tex-Mex comfort food classic!
PrintJohn Wayne Casserole Recipe
The John Wayne Casserole recipe is a delicious, layered dish made with seasoned ground beef, diced tomatoes, cheese, and vegetables, offering a perfect combination of savory flavors. Ideal for a hearty dinner, this casserole is great for feeding a crowd. Featuring southwestern-inspired ingredients, it’s sure to become a family favorite.
- Prep Time: 15 minutes
- Cook Time: 35 minutes
- Total Time: 50 minutes
- Yield: 8 servings 1x
- Category: Casserole
- Method: Baking
- Cuisine: American
- Diet: Gluten Free
Ingredients
- 2 lbs ground beef
- 1 packet taco seasoning
- 1 cup sour cream
- 1 cup mayonnaise
- 1 lb cheddar cheese, shredded
- 1 large onion, diced
- 1 bell pepper, diced
- 1 can diced tomatoes with green chiles (drained)
- 1 can biscuit dough
- 1 packet ranch dressing mix
- Salt and pepper to taste
Instructions
- Preheat oven to 350°F (175°C).
- Brown ground beef in a skillet, drain fat, then mix with taco seasoning and diced tomatoes.
- In a bowl, combine sour cream, mayonnaise, and ranch dressing mix.
- Layer biscuit dough at the bottom of a baking dish.
- Add the beef mixture on top of the dough.
- Spread the sour cream mixture over the beef layer.
- Top with diced onions, bell peppers, and shredded cheese.
- Bake for 30-40 minutes until the top is bubbly and golden.
- Let cool slightly before serving.
Notes
- You can add or substitute veggies to your preference, like jalapeños for extra heat.
- For a lower-carb version, omit the biscuit dough.
Nutrition
- Serving Size: 1 slice
- Calories: 550 kcal
- Sugar: 6g
- Sodium: 850mg
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