Looking for the ultimate comfort food that combines two family favorites into one delicious dish? Then you're in the right place! This Mac and Cheese Meatloaf Casserole Recipe is everything you need for a hearty meal, with the cheesy goodness of mac and cheese layered over a savory meatloaf base. Perfect for family dinners, potlucks, or any gathering, this casserole will become a staple in your recipe collection. Stick around to get the full recipe, plus tips on how to make it your own!

What is Mac And Cheese Meatloaf Casserole?
Mac and Cheese Meatloaf Casserole is a delicious and indulgent fusion of two classic comfort foods: the rich, cheesy, creamy goodness of mac and cheese paired with the robust, savory flavor of meatloaf. This dish takes the best elements of each and combines them into one incredible meal. The base is a classic ground beef meatloaf, topped with a generous layer of creamy mac and cheese, and baked to golden perfection. It's an irresistible combination that will satisfy your cravings for something hearty and comforting.
Ingredients List for Mac And Cheese
For the Mac and Cheese Layer:
- 8 oz elbow macaroni (or any pasta of your choice)
- 2 cups shredded cheddar cheese (sharp or mild)
- 2 tablespoon unsalted butter
- 2 tablespoon all-purpose flour
- 2 cups whole milk (or heavy cream for extra creaminess)
- ½ teaspoon garlic powder (optional but adds flavor)
- ½ teaspoon onion powder (optional)
- Salt and pepper to taste
- ¼ cup grated Parmesan cheese (for added richness)
- ½ cup panko breadcrumbs (for topping, optional)
For the Meatloaf Layer:
- 1 ½ lbs ground beef (80/20 ratio for optimal flavor)
- 1 small onion, finely chopped
- ½ cup breadcrumbs (plain or seasoned)
- ¼ cup ketchup
- 1 tablespoon Worcestershire sauce
- 1 large egg
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- ½ teaspoon smoked paprika (adds a subtle smoky flavor)
- Salt and pepper to taste
- ¼ cup milk (to keep the meatloaf moist)
Substitutions and Variations
There are plenty of ways to customize this Mac and Cheese Meatloaf Casserole to suit your personal preferences or dietary needs. Here are a few ideas for substitutions and variations:
- Ground Meat Substitutes: Instead of ground beef, you can use ground turkey, ground chicken, or even ground pork. A meatless version can be made using plant-based meat alternatives like Beyond Meat.
- Cheese Choices: While cheddar is classic for mac and cheese, you can experiment with other cheeses like mozzarella, gouda, or Monterey Jack for a different flavor profile. For a spicy kick, try pepper jack cheese.
- Pasta Variations: Elbow macaroni is traditional, but you can use shells, cavatappi, or penne for a twist. Whole wheat or gluten-free pasta options work too.
- Vegetable Add-Ins: Sneak in some veggies! Chopped spinach, grated carrots, or peas can be mixed into the mac and cheese for added nutrition.
- Topping Variations: For extra crunch, top the casserole with crushed crackers, more panko breadcrumbs, or crispy bacon bits. You could also drizzle extra ketchup or BBQ sauce over the meatloaf layer.
Step-by-Step Cooking Instructions

This recipe is straightforward, but it does require preparing both the meatloaf and mac and cheese separately before combining them into the casserole. Let's break it down step by step to make it as easy as possible.
Step 1: Prepare the Macaroni
- Bring a large pot of salted water to a boil. Add the macaroni and cook according to the package directions until al dente (usually 6-8 minutes). Drain and set aside.
Step 2: Make the Cheese Sauce
- In a large saucepan, melt the butter over medium heat. Add the flour and whisk constantly for 1-2 minutes to form a roux.
- Slowly add the milk while whisking, ensuring no lumps form. Continue stirring until the mixture thickens, about 3-5 minutes.
- Stir in the garlic powder, onion powder, salt, and pepper. Gradually add the shredded cheddar cheese and Parmesan, stirring until smooth and creamy. Remove from heat.
- Mix the cooked macaroni into the cheese sauce until well-coated. Set aside.
Step 3: Prepare the Meatloaf Mixture
- Preheat your oven to 350°F (175°C).
- In a large mixing bowl, combine the ground beef, chopped onion, breadcrumbs, ketchup, Worcestershire sauce, egg, garlic powder, onion powder, smoked paprika, salt, pepper, and milk. Mix everything together until just combined—avoid over-mixing to keep the meatloaf tender.
- Press the meatloaf mixture into the bottom of a greased 9x13-inch baking dish.
Step 4: Layer the Mac and Cheese
- Spread the prepared mac and cheese evenly over the top of the meatloaf layer in the baking dish.
- If desired, sprinkle panko breadcrumbs over the top for added crunch.
Step 5: Bake the Casserole
- Place the casserole in the preheated oven and bake for 45-50 minutes, or until the meatloaf is fully cooked through and the mac and cheese is bubbly and golden.
- If the top isn’t browning enough for your liking, you can broil it for an additional 2-3 minutes. Keep a close eye on it to avoid burning.
How to Cook Mac And Cheese Meatloaf Casserole: A Step-by-Step Guide
- Prep time: About 20 minutes to prepare both the meatloaf and mac and cheese layers.
- Bake time: 45-50 minutes in the oven.
- Total time: Expect around 1 hour and 15 minutes from start to finish.
- Tip: Use a meat thermometer to ensure the meatloaf reaches an internal temperature of 160°F (70°C) before serving.
- Tip: Allow the casserole to rest for about 10 minutes after baking to make slicing easier.
Common Mistakes to Avoid
- Overcooking the Macaroni: Make sure to cook the macaroni to al dente. Overcooked pasta will become mushy once baked.
- Overmixing the Meatloaf: Mixing the meatloaf ingredients too much can lead to a dense, tough texture. Combine just until everything is evenly distributed.
- Skipping the Resting Period: Letting the casserole rest for 10 minutes after baking helps the layers set and makes it easier to serve without falling apart.
- Dry Meatloaf: Ensure that you add enough moisture to the meatloaf mix (such as milk and breadcrumbs) to avoid a dry texture.
Serving and Presentation Tips
How to Serve Mac And Cheese Meatloaf Casserole
- Slice the casserole into squares or rectangular portions.
- Serve with a side salad, roasted vegetables, or garlic bread to balance the richness of the casserole.
- A drizzle of BBQ sauce or a side of ketchup works well if you want an extra hit of flavor.
Presentation Ideas for Mac And Cheese Meatloaf Casserole
- Garnish the casserole with freshly chopped parsley or chives for a pop of color.
- For added crunch and presentation, sprinkle crushed crackers or bacon bits on top before baking.
- Serve the casserole in individual ramekins for a fun, single-serve option.
Mac And Cheese Meatloaf Casserole Recipe Tips
- Prepping in Advance: You can make both the mac and cheese and meatloaf components in advance and refrigerate them separately. When ready to bake, layer them together in the casserole dish.
- Freezing: This casserole freezes well! Assemble it as directed but don’t bake it. Wrap it tightly in plastic wrap and foil, then freeze for up to 3 months. When you’re ready to bake, thaw it overnight in the fridge and bake as instructed.
- Cheese Mix: Mixing different kinds of cheese, like cheddar, gouda, and mozzarella, adds depth to the mac and cheese flavor.
Frequently Asked Questions (FAQs)
Can I use store-bought mac and cheese for this recipe?
Yes, if you’re short on time, you can use boxed mac and cheese. Just prepare it according to the package instructions and layer it over the meatloaf.
Can I make this casserole ahead of time?
Absolutely! You can assemble the casserole a day in advance and store it in the refrigerator. When ready to cook, simply bake as instructed.
What’s the best way to reheat leftovers?
Reheat individual portions in the microwave, or you can cover the entire casserole with foil and reheat in the oven at 350°F until warmed through.
Can I add vegetables to the meatloaf layer?
Yes! Finely chopped vegetables like carrots, zucchini, or bell peppers can be mixed into the meatloaf for added nutrition.
Conclusion
This Mac and Cheese Meatloaf Casserole recipe brings together two all-time favorites into one fantastic dish. With its creamy mac and cheese topping and juicy, flavorful meatloaf base, it's sure to please everyone at the table. Plus, it’s easy to customize with different cheeses, meats, or even veggies. Try this recipe today, and watch as it becomes a go-to meal for your family! Don't forget to bookmark this page for future reference and share the recipe with your friends!
Happy cooking!
PrintMac And Cheese Meatloaf Casserole Recipe
This mac and cheese meatloaf casserole recipe combines creamy mac and cheese with savory meatloaf, making it the ultimate comfort food. A perfect family dinner with ground beef, cheddar cheese, and pasta in a single dish that will satisfy all cravings.
- Prep Time: 20 minutes
- Cook Time: 40-45 minutes
- Total Time: 1 hour
- Yield: 6 servings
- Category: Casserole
- Method: Baking
- Cuisine: American
- Diet: Diabetic
Ingredients
- Ground beef
- Elbow macaroni
- Cheddar cheese
- Milk
- Butter
- Eggs
- Bread crumbs
- Onion
- Garlic
- Ketchup
- Mustard
- Worcestershire sauce
- Salt and pepper
Instructions
- Preheat oven to 350°F. Cook macaroni according to package instructions.
- In a bowl, mix ground beef, eggs, bread crumbs, chopped onion, garlic, Worcestershire sauce, ketchup, mustard, salt, and pepper.
- Press the meatloaf mixture into a greased casserole dish. Bake for 20 minutes.
- Meanwhile, make a cheese sauce by melting butter, stirring in flour, then adding milk and shredded cheddar cheese.
- Once the meatloaf has partially baked, layer the cooked macaroni and cheese sauce on top.
- Return to the oven and bake for another 20-25 minutes until bubbly and golden.
- Let it rest for 5 minutes before serving.
Notes
For a twist, add bacon bits or use a blend of cheeses for a richer flavor.
Nutrition
- Serving Size: 1 slice
- Calories: 520
- Sugar: 4g
- Sodium: 900mg
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